Do Biological Agents be Useful in the Treatment of Amyloidosis Related FMF?
نویسندگان
چکیده
Introduction Familial Mediterranean Fever (FMF), is an autosomal recessive disease associated with mutations in the MEFV gene, affecting mostly Mediterranean populations (Armenians, Arabs, Jewsand, Turks). It is characterized by self-limited recurrent attacks of fever and serositis [1]. Since 1972, colchicine is the standard treatment in FMF patients and majority of the patients achieve complete or partial remission together with colchicine therapy [2,3]. The most serious complication of FMF is AA-type amyloidosis, which can result in end-stage renal disease (ESRD) [4]. There is limited data on the treatment of amyloidosis caused by FMF in children. Abstract
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FMF Genotype-phenotype correlation in Iranian Azeri Turks: Association between M694V/R761H mutation and amyloidosis
Objective(s):Familial Mediterranean fever (FMF), an inherited autosomal recessive disorder, is frequently present among individuals of Mediterranean origin. Differences in the clinical manifestations of FMF between different ethnic groups have been documented. The aim of the present study was to determine the most common characteristics of FMF and the relationship between clinical findings and ...
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